The pharmacokinetics of caffeine are highly variable among individuals due to a polymorphism at the level of the CYP1A2 isoform of cytochrome P450, which metabolizes 95% of the caffeine ingested. The most common caffeine-containing beverages and foods are coffee, tea, cola, chocolate, and energy drinks (3–5). カフェインと薬の相互作用、CYP1A2に気をつける 関連ページ 不眠の原因を探る、睡眠環境や生活習慣 不眠の患者さんは多くいます。睡眠薬に頼らない自然な眠りを取ることができるのが一番です。不眠を解消するための睡眠環境や生活習慣の確認をして見直すことが重要です。 Komorita Y, Iwase M, Fujii H, Ohkuma T, Ide H, Jodai-Kitamura T, Yoshinari M, Oku Y, Higashi T, Nakamura U, Kitazono T. BMJ Open Diabetes Res Care. Individuals who are homozygous for the CYP1A2*1A allele are "rapid" caffeine metabolizers, whereas carriers of the variant CYP1A2*1F are "slow" caffeine metabolizers. caffeine, CYP1A2, genetic polymorphism, molecular epidemiology, recurrent pregnancy loss Introduction About 10–14% of clinically recognized pregnancies end in pregnancy loss in the Japanese population as well as in Caucasians. caffeine, CYP1A2, genetic polymorphism, molecular epidemiology, recurrent pregnancy loss Introduction About 10–14% of clinically recognized pregnancies end in pregnancy loss in the Japanese population as well as in Caucasians. Get the latest public health information from CDC: https://www.coronavirus.gov, Get the latest research information from NIH: https://www.nih.gov/coronavirus, Find NCBI SARS-CoV-2 literature, sequence, and clinical content: https://www.ncbi.nlm.nih.gov/sars-cov-2/. Vranceanu M, Pickering C, Filip L, Pralea IE, Sundaram S, Al-Saleh A, Popa DS, Grimaldi KA. Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice. CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study. 2020 Oct;8(1):e001252. 2021 Jan 2;18(1):1. doi: 10.1186/s12970-020-00383-4. Subjects were genotyped and classified as AA homozygotes or AC heterozygotes for the rs762551 polymorphism of the CYP1A2 gene involved in caffeine metabolism. The association of caffeine consumption with hypertension remains controversial. Genetics of Caffeine Consumption. A meta-analysis looked at the association between habitual coffee intake and CYP1A2 polymorphism that splits the population into fast caffeine metabolisers and slow caffeine … Corresponding ORs (95% CIs) for individuals with the rapid *1A/*1A genotype were 1.00, 0.75 (0.51-1.12), 0.78 (0.56-1.09), and 0.99 (0.66-1.48) (P = .04 for gene x coffee interaction). This site needs JavaScript to work properly. Furthermore, CYP1A2 activates several aromatic amines and thus is a key enzyme in chemical carcinogenesis [ 3 ]. This site needs JavaScript to work properly. 2006 Aug 16;296(7):764-5; author reply 765-6. doi: 10.1001/jama.296.7.764-b. It has been suggested that polymorphisms within CYP1A2 impact inter-individual variation in the response to caffeine. To systematically review studies that examined the influence of the CYP1A2 −163C>A polymorphism on the ergogenic effects of caffeine and to discuss some of the reasons for the discrepancies in findings between the studies. 2020 Oct;98(4):351-363. doi: 10.1124/mol.120.119412.  |  Material and Methods: Twenty male subjects participated in two 3 km cycling time trials 60 minutes following placebo (all-purpose flour) and caffeine (6 mg/kg BW anhydrous caffeine) … Polymorphism of CYP1A2 is known to cause interindividual variation on enzymatic activity, thus affects caffeine metabolism and its effect on cardiovascular (CV) system. We explored the effects of CYP1A2 variants and CYP1A2 enzyme activity on BP, focusing on caffeine as the potential mediator of CYP1A2 effects. The cytochrome P450 enzyme CYP1A2 plays a major role in metabolism of many commonly used drugs including clozapine, imipramine, caffeine, paracetamol, phenacetin, theophylline, tacrine [ 1 ], and some neurotoxins [ 2 ]. Palatini P(1), Benetti E, Mos L, Garavelli G, … 445-449 Cases (n = 2014) with a first acute nonfatal MI and population-based controls (n = 2014) living in Costa Rica between 1994 and 2004, matched for age, sex, and area of residence, were genotyped by restriction fragment-length polymorphism polymerase chain reaction. CYP1A2; circadian rhythm; genetics; mouthwash. doi: 10.1136/bmjdrc-2020-001252. Thirty-eight recreational cyclists completed four simulated 3-km time trials (TT). 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